32,099名结肠直肠癌患者的查史和7年生存率:基于人口的队列研究
Bo-Yu Hsiao1, Chun-Ju Chiang1,2, Ya-Wen Yang1,2
1Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Clinical epidemiology
|October 9, 2023
概括
在诊断前结肠直肠癌查史独立预测存活率. 从未进行查或在便免疫化学测试 (FIT) 呈阳性后推迟随访的患者面临更高的死亡风险.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 结肠直肠癌 (CRC) 查史对诊断后存活率的影响尚未完全理解.
- 在CRC诊断后任何查益处的持续性需要调查.
研究的目的:
- 为了确定CRC查史是否是生存的独立预测因素.
- 评估查的生存优势是否在CRC诊断后继续存在.
主要方法:
- 在台湾对32,099名CRC患者 (2013-2015) 进行了基于人口的队列研究.
- 利用台湾癌症登记,查计划数据和国家死亡登记 (2019年之前).
- 基于查史分析的生存结果:FIT阳性随访,FIT阳性没有随访,FIT阴性,从未进行过查.
主要成果:
- 与随访的FIT阳性患者相比,调整后的死亡危险比为:1.40 (FIT阳性,没有随访),1.63 (FIT阴性) 和1.76 (从未进行查).
- 对FIT阳性患者的延迟诊断 (>12个月) 增加了危险比率,在2年后达到1.2.
- 在FIT阴性患者中,危险比率约为2.0,在诊断后9个月后降至1.6.
结论:
- 诊断前的CRC查史是生存的独立预后因素,无论癌症的阶段如何.
- 医生应考虑患者查史,以优化诊断,随访和管理.
- 根据查史识别高风险患者可以改善CRC患者的治疗结果.
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