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相关概念视频

Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

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The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
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Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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相关实验视频

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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功能性便秘患者的改变内在功能性大脑结构:一个基于表面的网络研究.

Xiang Yu1, Jingjie Yu2, Yuwei Li3

  • 1Department of Radiology, Tianjin Union Medical Center, Tianjin, China.

Frontiers in neuroscience
|October 9, 2023
PubMed
概括

功能性便秘 (FCon) 与大脑网络组织的改变有关,影响视觉,情绪和运动功能. 在FCon患者中,这些大脑网络的变化可能会提供新的治疗点.

关键词:
功能连接性的功能连接性功能性便秘 功能性便秘图形理论分析 图形理论分析静止状态的fMRI进行.基于表面的分析分析.

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科学领域:

  • 神经科学是一个神经科学.
  • 胃肠病学 胃肠病学
  • 精神病学是一个精神病学.

背景情况:

  • 功能性便秘 (FCon) 是一种普遍存在的功能性胃肠道疾病 (FGID).
  • 患有FCon的患者经常表现出同时出现的精神疾病,如焦虑和抑郁症.
  • 将FCon与这些精神症状联系在一起的确切的病理生理机制尚未完全理解.

研究的目的:

  • 为了研究与健康对照组相比,FCon患者的异常功能性脑网络改变.
  • 探索大脑网络属性与FCon.Con.中的临床变量之间的关系.

主要方法:

  • 招募了35名FCon患者和40名健康对照 (HC).
  • 使用静止状态功能磁共振成像 (RS-fMRI) 与基于表面的分析 (SBA) 和图形理论分析 (GTA).
  • 在大规模大脑网络中和大脑网络之间分析功能连接 (FC).

主要成果:

  • FCon患者表现出改变的全球网络拓,包括增加集群系数,局部效率和最短路径长度,全球效率下降.
  • 在FCon患者的前端双关节网络 (FPN) 中观察到节点效率增加.
  • 在视觉,边缘,默认模式和体感运动网络中发现了显著的功能连接性改变.

结论:

  • 在FCon中改变的功能性大脑网络架构会影响视觉感知,情绪调节,感官运动处理和注意力控制.
  • 这些发现表明FCon.在FCon.中的新型治疗干预措施的潜在目标.