乳房植入物的功能化通过循环德克斯在位聚合:用于增强乳房整形的局部药物输送系统
Karen Escobar1, Ignacio Carrera1, Nelson Naveas2,3
1Department of Mathematical and Physical Sciences, UC Temuco, Temuco, Chile.
Frontiers in bioengineering and biotechnology
|October 9, 2023
概括
这项研究开发了使用环极 (CD) 进行可控药物输送的功能化乳房植入物. 这种新型的植入物显示出优越的特性,可以预防乳房整形术后的并发症,如感染和收缩.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 乳房整形,包括重建和美容手术,在术后面临诸如感染和囊收缩等风险.
- 环极素 (CD) 具有控制药物释放的潜力,有助于缓解这些并发症.
研究的目的:
- 为了使乳房植入物具有循环德克斯特林 (CD) 的功能,用于局部,可控的治疗分子输送.
- 研究这些功能化植入物在预防常见的乳房整形后并发症方面的疗效.
主要方法:
- 乳房植入物通过β-cyclodextrin/酸和2-hydroxypropyl-beta-CD/酸的现场聚合来实现功能.
- 用O2等离子体和酸盐接种的预处理提高了聚合率.
- 用于药物释放和疗效研究,功能化植入物装载了pirfenidone,Rose Bengal和KR-12.
主要成果:
- 功能化显著改善了植入物特性.
- 对皮尔芬尼,孟加拉和KR-12的受控释放动力学进行了表征.
- KR-12对斯塔菲洛科克斯 (Staphylococcus epidermidis) 和 Pseudomonas aeruginosa 具有抗菌作用.
- 与标准植入物相比,功能化植入物显示出较低的细胞毒性.
结论:
- 植入物的in-situ聚合式环氧素功能化创造了一个有效的局部药物递送系统.
- 这种方法提供了一种有前途的策略,可以预防乳房整形术后的并发症,从而改善患者的治疗结果.
- 与未受保护的植入物相比,开发的系统表现出优越的性能和安全性.
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