中枢神经系统缩和ICVD对执行功能和功能状态测试的影响是由智力介导的
Donald R Royall1,2,3,4, Raymond F Palmer3
1Department of Psychiatry, the University of Texas Health Science Center, San Antonio, TX, United States of America.
Cerebral circulation - cognition and behavior
|October 9, 2023
概括
缺血性脑血管疾病和前额缩影响执行功能 (EF) 和一般智力 (g). 生物标志物通过g影响残疾,而不是直接通过EF影响残疾,这表明前额叶功能与与痴呆有关的执行能力下降有所区别.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 神经学 神经学
背景情况:
- 执行功能 (EF) 障碍通常与缺血性脑血管疾病 (ICVD) 和额头病理有关.
- 一般情报 (g) 可以影响执行措施,需要区分这些构造.
- 了解神经成像生物标志物对EF和一般智能的影响至关重要.
研究的目的:
- 区分神经成像生物标志物对执行功能 (EF) 和一般智力 (g) 的影响.
- 研究成像生物标志物,认知表现和日常生活活动之间的关系.
主要方法:
- 使用多个指标多个原因 (MIMIC) 模型与阿尔茨海默病神经成像计划 (ADNI) (N ≈ 1750) 的数据.
- 测试了神经成像生物标志物作为12个月前性认知表现的独立预测因素.
- 检查了EF和一般智力因子 (dEF,来自斯皮尔曼的g) 的潜在变量.
主要成果:
- 缺血性脑血管疾病 (ICVD) 与"组织"和"规划"分数有关.
- 左前环膜体 (LAC) 缩独立预测了Trail-Making Part B和动物命名方面的表现.
- 只有一般智力系数 (dEF) 与日常生活的工具性活动 (IADL) 相相关;ICVD和LAC通过dEF影响了执行措施.
结论:
- 观察到的执行功能是多因素的;MRI生物标志物的对残疾和痴呆的影响是由一般智力 (g) 介导的.
- 额叶结构可能对执行措施的痴呆症特异差异不至关重要.
- 特定领域的执行功能变异可能独立于IADL损伤或痴呆症.
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