使用药物治疗来解决自闭症谱系障碍的睡眠障碍
Valeria Mammarella1, Silvia Orecchio1, Noemi Cameli1
1Child Neuropsychiatry Unit, Department of Human Neuroscience, Sapienza University, Rome, Italy.
Expert review of neurotherapeutics
|October 9, 2023
概括
睡眠障碍在自闭症谱系障碍 (ASD) 中很常见,并影响家庭. 梅拉是唯一具有足够治疗证据的药物,尽管可以考虑其他药物.
科学领域:
- 神经发育障碍 神经发育障碍
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 睡眠障碍是自闭症谱系障碍 (ASD) 中的显著并发症,影响儿童的行为,情绪和ASD核心特征.
- 患有自闭症儿童的失眠会对家庭的生活质量产生负面影响,强调需要有效的管理策略.
研究的目的:
- 审查ASD儿童 (0-18岁) 睡眠障碍药理疗法的科学证据.
- 通过澄清证据基础,指导临床医生选择合适的治疗方法.
主要方法:
- 对PubMed和Cochrane图书馆数据库的系统文献审查.
- 搜索词包括"自闭症谱系障碍"",药物治疗"和"睡眠障碍".
主要成果:
- 黑色素是唯一一个有足够证据治疗ASD睡眠障碍的化合物.
- 其他药物,如抗组胺剂,特拉佐,克洛尼丁,拉梅尔, gabapentin 和 suvorexant 可能会被考虑,但证据不那么强.
结论:
- 睡眠障碍的治疗是管理ASD的主要目标.
- 基于证据的药物选择,以黑激素为主要选择,对于改善ASD患者睡眠障碍的结果至关重要.
相关概念视频
01:19Management of Insomnia
266
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
266
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
188
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
188
01:19Autism Spectrum Disorder
119
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
119
01:28Drug Therapy
51
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
51
01:26Modeling in Therapy
104
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
104
01:17Sleepwalking and Sleep Talking
178
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
178