在衰老和衰老中的 lysosomes.
Jay Xiaojun Tan1,2, Toren Finkel1,3
1Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
EMBO reports
|October 9, 2023
概括
溶酶体功能障碍与衰老和疾病有关. 一个新定义的系统,溶酶体处理和适应系统 (LYPAS),适应压力,并可能为衰老提供治疗点.
科学领域:
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
- 分子机制的分子机制
背景情况:
- 溶解体是动物细胞中至关重要的水解器官.
- 溶酶体功能障碍与衰老和与年龄相关的疾病有关,导致细胞衰老或死亡.
- 将 lysosomal 功能障碍与细胞和生物体表型联系在一起的确切机制尚未完全理解.
研究的目的:
- 将调节 lysosomal 活动的协调细胞过程归类为 lysosomal 处理和适应系统 (LYPAS).
- 审查LYPAS在细胞应激反应,衰老和细胞死亡中的作用的证据.
- 探索LYPAS对与年龄相关的疾病和衰老的治疗潜力.
主要方法:
- 文献综述和现有关于 lysosomal 功能和调节的研究的综合.
- 在压力下参与 lysosomal 活动的细胞通路的分类.
- 分析证据,将LYPAS与细胞衰老和死亡途径联系起来.
主要成果:
- 溶解体是细胞应激反应的核心因其降解能力.
- lysosomal 处理和适应系统 (LYPAS) 是由各种细胞应激升级.
- LYPAS适应性在调节细胞衰老和细胞死亡之间的决策方面发挥着关键作用.
结论:
- LYPAS是压力下 lysosomal 功能的关键调节系统.
- LYPAS适应性影响细胞命运决策,影响衰老和疾病.
- 向LYPAS为与年龄相关的疾病和潜在的衰老本身提供了一个有前途的治疗策略.
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