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在自闭症谱系障碍 (ASD) 中治疗易怒,侵略和自我伤害的药物干预
Michelle Iffland1, Nuala Livingstone2, Mikaela Jorgensen1
1Senior Practitioner Branch, NDIS Quality and Safeguards Commission, Penrith, Australia.
The Cochrane database of systematic reviews
|October 9, 2023
概括
对自闭症谱系障碍 (ASD) 的药理干预显示出混合的结果. 非典型的抗精神病药物可能会减少易怒和自我伤害,但会带来不良反应 (AE) 的风险.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 药理干预通常用于管理自闭症谱系障碍 (ASD) 中具有挑战性的行为,例如易怒,侵略和自我伤害.
- 虽然一些药物可能有所帮助,但它们也可能导致不良反应 (AE).
研究的目的:
- 评估药理干预措施在治疗ASD患者易怒,侵略和自我伤害方面的有效性.
- 评估与这些干预相关的安全性和不良影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 搜索包括多个数据库和试验登记册,截至2022年6月.
- 包括的研究将药理干预与安慰剂,替代药物或ASD患者的标准护理进行比较.
主要成果:
- 非典型的抗精神病药物可能会减少易怒 (中度确定性证据) 并可能在短期内减少自我伤害 (低确定性证据),但可能会出现神经和代谢性AE.
- 与ADHD相关的药物可能会略微减少易怒 (低确定性证据),不确定的神经,代谢和心理AE的风险.
- 神经激素和抗抑郁药对易怒性几乎没有明显影响,报道的副作用很少.
结论:
- 非典型的抗精神病药物显示出对易怒的可能益处和对ASD自我伤害的潜在益处,需要对AE进行仔细监测.
- 治疗ADHD的药物可能会稍微改善易怒,但自我伤害的证据有限,副作用不确定.
- 目前关于神经激素和抗抑郁药在治疗自闭症相关行为方面的证据有限,报告的相关副作用很少.
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