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Updated: Aug 7, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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检测IGF-1变体的检测率及其对蛋白质结合的影响:对24万多名患者的研究

Ievgen Motorykin1, Jianying Mu1, Bradley S Miller2

  • 1Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA.

Clinical chemistry and laboratory medicine
|October 9, 2023
PubMed
概括

在0.45%的患者中检测到胰岛素样生长因子1 (IGF-1) 变体,其中大多数位于C端. 这些变异可能会影响IGF-1的活性,并且可能具有致病性,影响临床试验的解释.

关键词:
类似胰岛素的增长因子1 (IGF-1)质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量多形态主义的多态主义.变种变种的变种

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Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...