m7GHub V2.0:一种更新的数据库,用于解码N7甲基瓜诺辛 (m7G) 表转录组
Xuan Wang1,2, Yuxin Zhang2,3, Kunqi Chen4
1Department of Public Health, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Nucleic acids research
|October 9, 2023
概括
m7GHub v.2.0是一个更新的数据库资源,用于N7-甲基瓜诺辛 (m7G) RNA修改. 它提供了全方位的m7G位点和多种物种的疾病相关变异的综合集合,有助于表表表转录组研究.
科学领域:
- 对于RNA的表观遗传学
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- N7-甲基瓜诺辛 (m7G) RNA修饰在生物过程和疾病发病过程中起着至关重要的作用.
- 已经确定了数万个m7G站点,突出显示了对综合数据资源的需求.
- 以前的m7GHub数据库只关注人类mRNA的m7G网站.
研究的目的:
- 为了介绍m7GHub v.2.0,一个扩展和更新的资源m7G修改.
- 为多种物种和RNA类型提供m7G位点和相关变异的全面集合.
- 为了促进m7G数据的共享,注释和定制分析.
主要方法:
- 来自下一代测序 (NGS) 和牛津纳米孔直接RNA测序 (ONT) 的综合数据.
- 精选的m7G网站进入m7GDB (23个物种中的430,898个网站).
- 收集了与m7G相关的变体和与疾病相关的m7G-SNP,并将其转化为m7GDiseaseDB (156,206个变体,3,238个m7G-SNP).
- 开发了增强分析模块:m7GFinder和m7GSNPer.
主要成果:
- m7GHub v.2.0现在包括一个m7GDB,其中包括23个物种中的430,898个假设的m7G站点.
- m7GDiseaseDB拥有156,206种与m7G相关的变体,其中包括3,238种与疾病相关的m7G-SNP.
- 增强的分析模块 (m7GFinder,m7GSNPer) 可进行交互式数据探索.
结论:
- m7GHub v.2.0 作为 m7G 修改研究的宝贵集中资源.
- 扩展数据库有助于研究m7G在各种生理和疾病环境中的作用.
- 在www.rnamd.org/m7GHub2免费访问,促进更广泛的科学参与.
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