相关实验视频

Updated: Jul 14, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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BCL-x的替代拼接是由RBM25与BCL-x前mRNA中的G-四重复合体结合控制的

Ronan Le Sénéchal1, Marc Keruzoré1, Alicia Quillévéré1

  • 1Univ Brest; Inserm UMR1078; Etablissement Français du Sang (EFS) Bretagne; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, 22 avenue Camille Desmoulins, F-29200 Brest, France.

Nucleic acids research
|October 9, 2023
PubMed
概括

研究人员发现,拼接因子RBM25与BCL-x前mRNA中的特定RNA结构 (rG4) 结合. 这种相互作用促进了亲细胞亡的Bcl-xS异型的产生,为癌细胞重新敏感化疗提供了一个新的策略.

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