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Biochemical Measurement of Neonatal Hypoxia
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婴儿肝脏的生物化学不同于当前实验室接受的规范
Kaija-Leena Kolho1, Tapio Lahtiharju2, Laura Merras-Salmio3
1Department of Pediatric Gastroenterology, Children's Hospital, University of Helsinki, P.O. Box 281, FI-00029, Helsinki, Finland. kaija-leena.kolho@helsinki.fi.
European journal of pediatrics
|October 9, 2023
概括
健康的婴儿在第一年表现出更高的肝脏生物化学值. 母乳养与水平升高有关,这表明需要为阿兰氨基转移酶 (ALT) 和其他肝酶制定婴儿特定的参考范围.
科学领域:
- 儿科生物化学 儿科生物化学
- 新生儿健康 新生儿健康
- 临床化学 临床化学
背景情况:
- 目前肝脏生物化学的参考范围可能不准确地反映健康的婴儿.
- 婴儿养习惯被怀疑会影响肝脏酶水平.
研究的目的:
- 在健康的婴儿中建立肝脏生物化学参考范围.
- 为了研究养类型对婴儿肝酶水平的影响.
主要方法:
- 分析了619名健康的3个月和6个月大的婴儿血清样本.
- 使用西门子Atellica CH 930分析仪测量氨酸胺转移酶 (ALT),AST,ALP,GGT和胆红素水平.
- 对婴儿长度跟踪至36个月.
主要成果:
- 在3个月后,ALT,AST,ALP,GT和胆红素的上90%置信区间高于当前的实验室极限.
- 升高的ALT和AST水平在6个月内持续存在,养类型与变化显著相关.
- 与配方奶粉养的婴儿相比,母乳养的婴儿表现出更高的ALT,AST和胆红素水平.
结论:
- 婴儿肝脏生物化学的确定的参考范围对于准确的诊断至关重要.
- 养类型,特别是母乳养,会影响婴儿的肝酶水平.
- 需要进一步的研究来确定儿科肝功能测试的年龄和养特定参考值.
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