开发一个冲绳小组,用于对冲绳人的生物地理推断
Hiroaki Nakanishi1,2, Vania Pereira3, Claus Børsting3
1Department of Forensic Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Annals of human biology
|October 9, 2023
概括
开发了一个由22个单核酸多态 (SNP) 标记器组成的新面板,以区分冲绳日语和日本大陆日语. 虽然与其他东亚团体没有完全区别,但这个SNP小组显示出对有限资源的法医调查有希望.
科学领域:
- 人口遗传学 人口遗传学
- 法医科学 法医科学
- 人类祖先的血统
背景情况:
- 以前的SNP小组,包括165标记精密ID祖先小组,未能区分大陆日本人,冲绳日本人和其他东亚人口.
- 冲绳日语和日本大陆日语之间的遗传区别需要进一步调查.
研究的目的:
- 制定一个有针对性的SNP小组,以改善对冲绳日本人与日本大陆和其他亚洲人群的歧视.
- 为了有效的基因分化,识别一组最小的单核酸多态 (SNP).
主要方法:
- 从现有文献中选择了75个信息性的SNP,以及额外的22个SNP用于最小的标记差异化.
- 使用STRUCTURE,主要组件分析 (PCA) 和GenoGeographer对48名日本大陆和46名冲绳日本人的遗传数据进行分析.
主要成果:
- 75-SNP和22-SNP组在结构分析和PCA分析中都显示出可比的差异化水平.
- 在46名冲绳日本人中,GenoGeographer的分析成功地为32人 (75名SNP) 和31人 (22名SNP) 分配了最可能的原始人群.
结论:
- 开发的22-SNP面板为区分冲绳日语提供了一个实用的工具,在样本数量,成本和时间受到限制的法医调查中具有潜在的应用.
- 与所有其他亚洲群体的完全差异化并未实现,但该小组为特定的人口比较提供了增强的分辨率.
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