社区参与的基础科学在一个NCI指定的综合癌症中心:抗氧化剂和化疗疗效率
Dominique Bollino1,2, Nathaniel Woodard3, Kayla M Tighe2
1School of Medicine, University of Maryland Baltimore, Baltimore, MD, USA.
Cancer causes & control : CCC
|October 9, 2023
概括
社区的投入指导了一项关于抗氧化剂和化疗的研究. 研究结果表明,抗氧化剂不能提高基化疗的疗效,并且可能阻碍其,特别是绿茶提取物. 这种模式将社区参与与基础癌症研究相结合.
科学领域:
- 在瘤学瘤学.
- 翻译癌症研究 翻译癌症研究
- 社区参与的研究
背景情况:
- 在癌症研究中,社区参与至关重要,但在基础/翻译/临床研究中不那么融入.
- 国家癌症研究所现在强调社区外展和参与癌症中心支持资助.
- 开发成功的模型,将社区投入纳入临床前癌症研究是必不可少的.
研究的目的:
- 试点一种社区参与的,数据驱动的方法,为临床前癌症研究提供信息.
- 研究常用的抗氧化剂对基化疗药物的疗效的影响.
主要方法:
- 一项调查确定了马里兰大学格林巴姆综合癌症中心 (UMGCCC) 收获区 (n=120) 居民中常用的抗氧化剂.
- 使用非小细胞肺癌 (A549),结肠腺癌 (SW620) 和头状细胞癌 (FaDu) 模型在体外评估了与剂结合选择的抗氧化剂 (维生素C,绿茶,黑激素) 的效果.
- 在体内研究评估了抗氧化剂-化疗组合对相关临床前模型中的瘤生长的影响.
主要成果:
- 在体外,抗氧化剂没有强化基化疗剂的抗瘤活性;大多数组合显示出对抗作用.
- 在体内,抗氧化剂补充剂没有提高化疗疗效.
- 具体来说,甲基酸 (来自绿茶) 在头癌模型中显著阻碍了西斯普拉丁介导的瘤生长抑制.
结论:
- 目前的研究结果不支持使用抗氧化剂补充剂来提高基化疗的有效性.
- 这项研究表明了将社区参与与瘤学基础科学研究相结合的可行模型.
- 需要进一步的研究来了解抗氧化剂和化疗之间的复杂相互作用.
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