抗高血压效应,ACE抑制活性和酵母提取物的Umami的稳定性
Jincheng Zhang1,2,3, Li Liang1,2,3, Yimeng Shan1,2,3
1Food Laboratory of Zhongyuan, Beijing Technology and Business University, Beijing 100048, China.
酵母提取物中的UmamiLLLLPKP通过抑制血管素I转化酶 (ACE) 有效降低高血压大鼠的血压. 这种生物活性在消化过程中表现出稳定性,并且在长期高血压管理方面具有有前途的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 来自食物来源的生物活性因其在治疗高血压方面的治疗潜力而越来越受认可.
- 酵母提取物是的丰富来源,具有潜在的健康益处.
研究的目的:
- 研究从酵母提取物中提取的乌玛米的抗高血压作用和潜在机制.
- 在自发高血压的老鼠模型中评估LLLLPKP的疗效.
主要方法:
- 利用药模型,模拟胃肠道消化,自发高血压大鼠 (SHR) 模型和分子对接.
- 在体外和体内评估了血管素I转化酶 (ACE) 抑制活性.
- 分析了的稳定性和与ACE活性部位的相互作用.
主要成果:
- 乌玛米LLLLPKP在体外表现出显著的ACE抑制活性 (IC50 = 10.22μM),并有效调节了SHR大鼠的血压,并具有持续的耐久性.
- 在LLLLPKP中,具有高药模型Fitvalue (4.022),这表明具有类似于ACE抑制剂的效果.
- 该在模拟消化过程中表现出了显著的稳定性,ACE抑制率降低了很少 (5.89%),并保留了与ACE活性部位相互作用的关键残留物 (L4,P5,K6,P7).
结论:
- LLLLPKP是一种强大的抗高血压,具有持久的效果,可能通过ACE抑制进行介导.
- 它在消化过程中的稳定性和与ACE活性位点的特定相互作用凸显了其治疗前景.
- 开发LLLLPKP对于高血压的长期管理具有重大潜力.
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