HPV-TP53-MALAT1轴:揭示宫癌发展中的相互作用
Saba Iordanishvili1, Tornike Metreveli1, Elene Lipartia1
1Petre Shotadze Tbilisi Medical Academy, Tbilisi, Georgia.
PloS one
|October 9, 2023
概括
高风险的人类乳头瘤病毒 (HPV) 感染与宫癌中的TP53基因多态和MALAT1过度表达有关. 这些因素显著相关,表明在HPV驱动的致癌过程中发挥了作用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 子宫癌是全球主要的健康问题,主要是由人类乳头瘤病毒 (HPV) 引起的.
- TP53基因的Arg72Pro多态性和像MALAT1这样的长非编码RNA (lncRNA) 与癌症发展有关.
- 了解它们在与HPV相关的宫癌中的相互作用至关重要.
研究的目的:
- 调查HPV感染,TP53 Arg72Pro多态性和宫癌中MALAT1表达之间的关联.
- 探索这些因素在宫癌发展中的潜在作用.
主要方法:
- 对TP53Arg72Pro多态性的基因定型.
- 使用qRT-PCR对MALAT1表达的量化.
- 对HPV状态,TP53多态和MALAT1表达的统计分析.
主要成果:
- 在HPV阳性受试者中观察到TP53 Arg72Pro多态性的高患病率.
- 马拉特1过度表达与高风险HPV阳性 (p<0.01) 和TP53 Pro72Pro多态性显著相关.
- 在HPV阴性样本中没有发现MALAT1表达的显著变化.
结论:
- 在宫癌中,HR-HPV感染,TP53多态化和MALAT1表达显著交织在一起.
- 需要进一步研究MALAT1与TP53在HPV相关癌症发生中的分子作用.
- 这些发现可能会导致针对性治疗和与HPV相关的宫癌的预后标志物.
相关概念视频
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
The Intrinsic Apoptotic Pathway
6.6K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.6K
Loss of Tumor Suppressor Gene Functions
4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.9K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
DNA Damage can Stall the Cell Cycle
9.2K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K

![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
