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相关概念视频

Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

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Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
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ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

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In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Rab Cascades01:25

Rab Cascades

2.7K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

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The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
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Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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一个基于的多站点组件的整体驱动组装 [2] 半氧化.

Ryan Djemili1, Sonia Adrouche1, Stéphanie Durot1

  • 1Laboratoire de Synthèse des Assemblages Moléculaires Multifonctionnels Institut de Chimie de Strasbourg, CNRS/UMR 7177, Université de Strasbourg, 4 rue Blaise Pascal, 67000 Strasbourg, France.

The Journal of organic chemistry
|October 9, 2023
PubMed
概括

研究人员使用含有pyrazine的子和-氨酸子组装了一个 [2]semirotaxane. 银离子驱动了组装,而离子触发了拆卸,展示了可控制的分子机械.

科学领域:

  • 超分子化学 超分子化学
  • 协调化学 协调化学
  • 材料科学 材料科学 材料科学

背景情况:

  • 分子组件的自我组装对于创建复杂的功能架构至关重要.
  • 罗塔克桑和半罗塔克桑是关键的超分子结构,在分子机器中具有潜在的应用.
  • 金属有机提供可调节的腔和结合点,用于分子识别和封装.

研究的目的:

  • 报告一种新的 [2] 半氧化结构的合成和特征.
  • 用金属离子研究罗塔xane形成的全性控制.
  • 为了证明在对特定刺激的反应中,超分子组件的分解.

主要方法:

  • 一个pyrazine功能化的半子组件的合成.
  • 构建一个具有多个结合点的bis-Zn(II) 氨酸.
  • 通过银(I) 离子协调.
  • 核磁共振 (NMR) 光谱用于结构阐明和监测.
  • 使用化物离子对刺激有反应的拆解.

主要成果:

  • 通过将半个子线连接到氨酸子中,成功组装了一种 [2] 半米罗塔克桑.
  • 已经证明了的控制:银 (I) 离子通过与子连接器的协调来促进线程过程.

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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
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  • 离子被证明会破坏 [2] 半氧化组件的稳定性,导致组件的释放.
  • 核磁共振研究证实了组装和拆卸过程中的结构完整性和动态变化.

    • 结论:

    • 这项研究介绍了一种新的金属离子驱动自组装的 [2] 半.
    • 这些发现突显了使用全控制用于动态分子架构的潜力.
    • 证明的刺激响应分解为可切换的超分子系统提供了一条途径.