对抗抑郁药物的反应中神经代谢物变化:对H-MRS发现的系统审查
Daphne E Boucherie1, Liesbeth Reneman2, Henricus G Ruhé3
1Amsterdam UMC, Location AMC, Department of Radiology and Nuclear Medicine, Meibergdreef 9, 1109 AZ Amsterdam, the Netherlands.
NeuroImage. Clinical
|October 9, 2023
概括
选择性血红素再吸收抑制剂 (SSRI),血红素和上腺素再吸收抑制剂 (SNRIs) 和抑郁症治疗药物 (es) ketamine 药物对大脑神经递质有不同的影响. (Es) 胺可能会在特定的大脑区域增加谷氨酸,与缺乏一致发现的SSRI/SNRIs不同.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 放射学 放射学是一门学科.
背景情况:
- 大型抑郁症 (MDD) 用SSRI,SNRIs和 (es) ketamine进行治疗.
- 这些药物可能会影响涉及MDD的谷氨酸和GABAergic系统.
- 质子磁共振光谱 (1H-MRS) 可以测量这些神经递质系统.
研究的目的:
- 系统地审查1H-MRS研究的SSRI,SNRIs和 (es) 基他胺对谷氨酸和GABAergic系统的影响.
- 为了探索健康志愿者和MDD患者的药物效应.
主要方法:
- 对PubMed,Web of Science和Embase数据库进行系统审查.
- 包括使用1H-MRS或MRSI (>1.5 T) 评估谷氨酸,谷氨酸胺,GLX或GABA的随机对照试验和队列研究.
- 在抗抑郁药治疗和安慰剂/基线之间比较代谢物水平.
主要成果:
- 其中包括29项研究,15项关于SSRI/SNRIs,14项关于 (es) ketamine.
- SSRI/SNRI研究是可变的,功能不足,并没有显示出一致的发现.
- (Es) 基他胺研究是可变的,但随着时间的推移,它表明前带皮质皮质中谷氨酸的增加.
结论:
- 目前对这些抗抑郁药的1H-MRS研究非常多变,对SSRI/SNRIs缺乏一致的发现.
- 进一步的研究需要标准化的协议和动态代谢物测量或组合成像技术.
- 需要标准化的1H-MRS协议来澄清抗抑郁药的神经代谢作用.
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