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相关概念视频

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

5.2K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.9K

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相关实验视频

Updated: Jul 14, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
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In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

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使用人类多能干细胞来剖析 trofhoblast 的发育.

Daisuke Suzuki1, Kuan-Chun Lan1, Yasuhiro Takashima1

  • 1Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Current opinion in genetics & development
|October 9, 2023
PubMed
概括

纯粹的人类多能干细胞 (PSCs) 可以分化为热囊细胞,提供对早期人类发育的见解. 本综述探讨了细胞分化的途径,从原始和原始的人类PSCs in vitro.

科学领域:

  • 发育生物学 发展生物学
  • 干细胞生物学 干细胞生物学
  • 生殖生物学 生殖生物学

背景情况:

  • 人类多能干细胞 (PSC) 存在于天真和原始状态,表现出明显的发育潜力.
  • 热囊细胞的发育对于囊胞的形成和植入至关重要.
  • 之前的研究表明,热囊细胞与原始化PSC的差异化.

研究的目的:

  • 审查来自人类PSCs的热囊细胞的体外分化.
  • 为了比较热囊细胞分化途径与天真和原始的人类PSC.
  • 讨论对理解体内热囊细胞发育的含义.

主要方法:

  • 对人类PSC分化成热囊细胞的现有文献的综述.
  • 在体外模型的分析,以对热囊细胞进行规范.
  • 对原始和原始的PSC差异化协议进行比较的讨论.

主要成果:

  • 纯粹的人类PSCs可以通过特洛菲克特皮 (TE) 样细胞分化为特洛菲布拉斯.
  • TE代表了热囊细胞发育的植入前阶段.
  • 实验室差异化表明,在体内,细胞可能会产生细胞的细胞潜力.

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Derivation of Mouse Trophoblast Stem Cells from Blastocysts
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Last Updated: Jul 14, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
08:21

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Derivation of Mouse Trophoblast Stem Cells from Blastocysts
10:19

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

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Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells
08:57

Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells

Published on: July 25, 2016

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结论:

  • 人类PSC是研究 trofhoblast 发育的宝贵工具.
  • 热囊细胞与原始和原始的PSC分化存在不同的途径.
  • 了解这些途径有助于研究早期人类胚胎发生和植入.