在COVID-19幸存者的长期创伤后压力症状及其风险因素:为期两年的纵向队列研究
Yanzhi Bi1, Yian Xiao1, Xinyu Pan1
1CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China.
Psychiatry research
|October 9, 2023
概括
COVID-19幸存者,特别是女性,经历了长期的心理健康问题,如PTSD和抑郁症. 社会支持对于恢复至关重要,脑部成像显示杏仁体和海马体活动发生变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,COVID-19大流行已经造成了重大的心理健康挑战.
- 需要进行长度研究,以了解幸存者持续存在的心理健康问题.
- 研究神经机制和风险因素对于有效的干预至关重要.
研究的目的:
- 为了检查COVID-19幸存者的纵向心理健康变化.
- 为了确定与幸存者的心理健康问题相关的风险因素.
- 通过脑成像来探索这些变化背后的神经机制.
主要方法:
- 招募了COVID-19幸存者和非COVID-19控制组在退院后3个月,6个月和2年.
- 收集有关人口统计,心理健康,社会支持和暴露的数据.
- 在2年的随访期间获得的大脑成像数据 (MRI).
主要成果:
- 与对照组相比,女性幸存者显示出更高的创伤后应激症状 (PTSS) 和2年的抑郁症,以及6个月的焦虑.
- 男性幸存者在2年后表现出高PTSS,抑郁和焦虑.
- 与COVID相关的创伤和较低的社会支持被确定为PTSS和负面情绪的风险因素. 神经成像显示男性桃体活动增加和海马活动与抑郁症和社会支持相关.
结论:
- COVID-19幸存者需要持续的心理健康监测.
- 社会支持在缓解COVID-19后的心理健康问题方面发挥着至关重要的作用.
- 杏仁体和海马体中大脑活动的改变与幸存者的心理健康结果有关.
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