基托纳米凝的反应动力学通过基因交叉连接
Xinyue Zhao1, Jian Tang2, Yanhua Liu3
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.
Journal of chromatography. A
|October 9, 2023
概括
基托的基尼交联形成生物相容的纳米凝. 研究了反应动力学和结构变化,揭示了尺寸依赖的交联和均的纳米凝形成,增加了疏水性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 奇托是一种具有生物相容性质的天然聚合物.
- 吉尼平是一种用于形成水凝的天然交叉连接剂.
- 奇托-基尼纳米凝在药物输送和组织工程方面具有潜在的应用.
研究的目的:
- 为了研究基托与基尼交叉连接的反应动力学.
- 在交叉连接过程中分析基托纳米凝的结构和构造演变.
- 了解影响均尺寸纳米凝形成的因素.
主要方法:
- 奇托和基尼在37°C的乙酸缓冲体中发生反应.
- 多检测不对称流场流量分成法 (AF4) 用于分析纳米凝大小,摩尔质量和旋转半径.
- 测量了电荷密度和疏水性变化的变化.
主要成果:
- 基托桑纳米凝尺寸 (Rhz) 从26nm增加到130nm,而摩尔质量 (Mw) 从2.0×105g/mol增加到1.8×107g/mol.
- 交叉连接反应是第一阶级和尺寸依赖的,有利于更大的纳米凝的链内交叉连接.
- 纳米凝的形成涉及降低电荷密度和增加水性,导致具有高链密度 (高达0.45g/cm3) 的均尺寸.
结论:
- 基尼交叉连接有效地产生生物相容的基托纳米凝.
- 反应动力学和结构演变取决于纳米凝的大小.
- 控制的电荷变化和疏水性对于形成均的基托纳米凝至关重要.
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