生活质量和认知在不同多病态模式中的轨迹:来自SHARE的证据
Tongxing Li1, Wei Hu1, Qiang Han1
1Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, China.
Archives of gerontology and geriatrics
|October 9, 2023
概括
这项研究表明,多病症模式显著影响老年人认知功能和生活质量 (QoL) 轨迹. 早期监测认知对于管理诸如骨关节炎和心脏代谢疾病等疾病至关重要.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 认知科学 认知科学
背景情况:
- 多病性,即多种慢性疾病的共存,在老年人群中很普遍.
- 了解认知功能与生活质量 (QoL) 在多种多重疾病模式之间的相互作用,对于有效的医疗保健至关重要.
- 欧洲健康,衰老和退休年龄调查 (SHARE) 提供了一个强大的数据集,用于调查这些复杂的关系.
研究的目的:
- 调查认知功能和 QoL 在老年人不同多病症模式的纵向轨迹.
- 分析这些独特的多病症组内认知功能和QoL之间的双向关联.
主要方法:
- 隐性类分析 (LCA) 用于从50岁以上的大群 (n=16,153) 中识别明显的多病态模式.
- 线性混合模型 (LMM) 检查了每个已识别的模式的认知和QoL随时间的变化速度.
- 交叉差距模型评估了认知和QoL之间的双向关系.
主要成果:
- 确定了四种多病症模式:高并发症负担 (HC),低并发症负担 (LC),心脏代谢 (CA) 和骨关节炎 (OS).
- HC组表现出最低的认知功能和QoL. 操作系统组显示了情节性记忆的最快下降.
- 发现认知和QoL之间存在显著的双向关联,认知功能对CA和LC组的QoL产生更大的影响.
结论:
- 认知和QoL下降率在不同的多病态模式中差异很大.
- 患有四种或更多慢性疾病的人需要特别注意.
- 积极监测认知功能可以减轻认知衰退和降低QoL之间的负反循环,特别是在OS或CA条件的患者中.
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