基于酸盐的复合材料含有甲基酸与甲基酸交联的奇托及其Cu (II) 复合物,作为一种无抗生素的抗菌水凝敷料,具有增强的细胞相容性
Khodayar Gholivand1, Mahnaz Mohammadpour1, Hossein Derakhshankhah2
1Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran.
International journal of biological macromolecules
|October 9, 2023
概括
新的酸盐-酸盐复合液凝显示出作为先进的伤口带的前景. 这些材料具有可调节的特性和显著的抗菌作用,可能成为有效的无抗生素伤口愈合解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 伤口愈合技术 伤口愈合技术
背景情况:
- 基于基托桑和酸盐的水凝因其在皮肤病变管理方面的潜力而得到认可.
- 开发具有增强性质的先进伤口包裹对于有效的伤口愈合至关重要.
研究的目的:
- 探索一系列新型的甲基酸盐 (Alg) 复合水凝,其中包括交联酸盐 (CSPN),用于伤口包应用.
- 研究这些复合水凝的合成,表征和性能,包括它们的抗菌功效.
主要方法:
- 交联酸盐 (CSPN) 和其Cu (II) 复合物的合成,然后与离子进行离子交联,以与酸盐形成水凝.
- 使用FTIR,XRD,风学技术,热分析 (TGA,DSC) 和基于DFT的结构优化进行表征.
- 评估水凝的特性,包括孔隙结构,胀,降解,蛋白质吸收,药物输送,细胞相容性 (MTT测定) 和抗菌活性.
主要成果:
- 分子被有效地吸附在CSPN和CSPN-Cu颗粒上,影响水凝的特性.
- 可调节的孔径大小,胀,降解和蛋白质吸收通过不同的CSPN和CSPN-Cu含量来实现.
- 开发的水凝表现出良好的细胞兼容性和显著的抗菌活性,由于Cu (II) 的存在,与抗生素包裹相似.
- 药物捕获和释放研究显示了药物输送应用的潜力.
结论:
- 合成的基于Alg的复合水凝在伤口愈合应用中表现出有前途的特性.
- 这些水凝由于其固有的抗菌特性,为伤口带提供了潜在的无抗生素替代品.
- 这些材料的可调和可生物降解性质表明,在先进的伤口护理中,未来将是光明的.
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