基于由呼吸道形态引起的鼻气动力学,对运动诱导的鼻炎的洞察力
Sarah M Russel1, Raluca E Gosman2, Katherine Gonzalez2
1University of North Carolina - Chapel Hill, Department of Otolaryngology/Head & Neck Surgery, Chapel Hill, NC, USA; Duke University Medical Center, Department of Head and Neck Surgery & Communication Sciences, Durham, NC, USA.
Respiratory physiology & neurobiology
|October 9, 2023
概括
不同的鼻子形状可能会影响运动诱发性鼻炎 (EIR). 划痕的鼻腔前庭显示出更高的阻力和空气流速,而标准表型提供更好的粘膜冷却,可能会影响EIR的发展.
科学领域:
- 鼻腔气流动力学 鼻腔气流动力学
- 计算流体动力学的流体动力学.
- 鼻炎研究研究 鼻炎研究
背景情况:
- 运动诱导的鼻炎 (EIR) 了解得很少.
- 增加的吸入气流可能会导致EIR.
- 描述EIR发展对于识别有助于发展的因素至关重要.
研究的目的:
- 分析不同鼻腔形态如何响应空气流.
- 在快速/深入吸入过程中调查与空气流相关的变量.
主要方法:
- 从放射图像中重建了对象特定的鼻腔气道.
- 根据前庭形态学,单边气道被分为标准形,形或延长形的表型.
- 在不同的空气流速下进行了计算流体动力学模拟.
主要成果:
- 划痕的表型在所有流速中表现出最高的鼻腔前庭阻力,空气流速和墙面剪切应力.
- 标准表型表现出最高的平均粘膜热量流.
- 划痕的表型显示,计算变量的百分比增加较小,从10L/分钟到50L/分钟.
结论:
- 划痕的表型表明更狭窄的鼻腔前庭,导致更高的阻力和速度.
- 标准的表型似乎有利于冷却鼻腔粘膜.
- 截然不同的鼻表型可能会使个体易患运动诱导的鼻炎.
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