在两个儿科ARDS队列中识别分子亚现象型
Nadir Yehya1, Matt S Zinter2,3, Jill M Thompson4
1Division of Pediatric Critical Care, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA yehyan@email.chop.edu.
Thorax
|October 9, 2023
概括
研究人员使用生物标志物分析在儿科急性呼吸困扰综合征 (ARDS) 中确定了明显的低炎症和高炎症亚表型. 这些亚现象与疾病严重程度和死亡率相关,有助于在未来的临床试验中对患者进行分层.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 呼吸系统药物 呼吸系统药物
- 发现生物标志物的发现.
背景情况:
- 急性呼吸窘迫综合征 (ARDS) 在成年人中呈现出低炎症和高炎症亚表型.
- 这些ARDS亚表型在儿科患者群体中的临床相关性仍未得到充分研究.
- 之前的研究表明,儿童有不同的ARDS亚型,需要进一步验证.
研究的目的:
- 在两个独立的儿科ARDS队列中识别和描述子类型.
- 评估已识别的儿科ARDS亚表型与先前描述的成人亚表型的一致性.
- 评估已识别的儿科ARDS亚表型的预后效用.
主要方法:
- 隐性类分析 (LCA) 用于来自两个儿科ARDS队列的生物标志物数据.
- 根据与炎症和内皮病相关的差异性生物标志物表达定义了亚表型.
- 临床特征,结果和与成年亚现象型的重叠被使用温和分类器评估.
主要成果:
- 在两个儿科ARDS队列中,确定了两个不同的亚现象型,即低炎症和高炎症.
- 超炎性亚表型与疾病严重程度增加,败血症发病率增加和死亡率显著增加有关.
- 已识别的儿科亚表型与成人ARDS亚表型有重叠的证据.
结论:
- 在两个队列中确定并验证了儿科ARDS的明显的低炎症和高炎症亚表型.
- 这些生物标志物定义的亚表型具有预后价值,并有可能在临床试验中进行预测丰富.
- 未来的儿科ARDS研究和临床试验应纳入这些亚表型,以改善分析和患者分层.
相关概念视频
Acute Respiratory Failure-II
252
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
252
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Pulmonary Hypertension: Classification and Pathogenesis
198
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
198
Acute Respiratory Failure-I
223
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
223


