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相关概念视频

Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

8.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.3K
Olfaction01:25

Olfaction

44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.4K

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相关实验视频

Updated: Jul 14, 2025

A Free-breathing fMRI Method to Study Human Olfactory Function
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A Free-breathing fMRI Method to Study Human Olfactory Function

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通过三胞胎激进剂量化嗅觉的周围调制.

Federica Genovese1, Jiang Xu2, Marco Tizzano2

  • 1Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 fgenovese@monell.org.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|October 9, 2023
PubMed
概括

由气味剂激活三角质会减少鼻子中的嗅觉反应. 这种调节在嗅觉感官转导的早期观察到,取决于三角管道的激活,影响嗅觉感知.

科学领域:

  • 神经科学是一个神经科学.
  • 感官生物学 感官生物学
  • 嗅觉研究 嗅觉研究

背景情况:

  • 哺乳动物的嗅觉包括嗅觉和三胞胎系统.
  • 三胞胎激活调节嗅觉反应,但机制尚不清楚.
  • 嗅觉上皮质 (OE) 是感觉神经元和三角纤维相互作用的地方.

研究的目的:

  • 研究三角体激活如何调节OE中的嗅觉反应.
  • 通过气味剂来表征三角质激活.
  • 确定TRPA1和TRPV1通道在这种调制中的作用.

主要方法:

  • 用于Ca2+成像的三神经元 (TGNs) 的初级培养.
  • 野生型 (WT) 和TRPA1/V1-Knockout (KO) 类小鼠的电 Olfactogram (EOG) 记录.
  • 经过三角体激动剂刺激后测试的气味2-乙醇 (PEA) 反应.

主要成果:

  • 三原体激动剂降低了对PEA的EOG反应.
  • 这种降低与TRPA1和TRPV1激活水平相关.
  • 三胞胎激活在最早的感官转导阶段影响嗅觉反应.
关键词:
化学是这些过程中的一个.化学传感器是一种化学传感器.嗅觉 嗅觉是一种嗅觉.生理学 生理学 生理学

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Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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相关实验视频

Last Updated: Jul 14, 2025

A Free-breathing fMRI Method to Study Human Olfactory Function
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A Free-breathing fMRI Method to Study Human Olfactory Function

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Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
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Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

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结论:

  • 三胞胎系统的激活显著减少了OE中的嗅觉反应.
  • 这种调制取决于激活剂的三等子强度.
  • 研究结果揭示了早期的三角体对嗅觉信号处理的影响.