视网膜光学一致性断层扫描血管学质量评估的OSCAR-MP共识标准
Rebecca Wicklein1, Charmaine Yam1, Christina Noll1
1From the Department of Neurology (R.W., C.N., L.A., N.B., E.F.R., E.W., B.H., B.K.), Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Germany; Department of Neuroinflammation (C.Y., O.C., A.P., A.T.T.), Queen Square MS Centre, Faculty of Brain Sciences, UCL Queen Square Institute of Neurology, University College London; Neurosciences Institute (C.Y.), Cleveland Clinic London, United Kingdom; Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany; Experimental and Clinical Research Center (F.C.O., H.Z., F.P.), Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Einstein Center Digital Future (H.Z.), Berlin; Department of Neurology (P.A., M.R.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine University Düsseldorf; Department of Neurology (P.A.), Maria Hilf Clinics, Mönchengladbach; Department of Ophthalmology (C.B., N.F.), Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Germany; Department of Ophthalmology (J.P.), University of Basel, Switzerland; Airport Munich Eye Clinic MVZ (N.F.), Germany; Department of Ophthalmology (J.P.), University of Basel, Switzerland; Institute of Clinical Neuroimmunology (J.H., J.A.G.), LMU Hospital, Ludwig-Maximilians-Universität München, Munich; Department of Ophthalmology (C.M.), Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Department of Neurology (E.S.V., P.A.C., S.S.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neuroscience (A.V.D.W.), Central Clinical School, Monash University, Melbourne, Victoria, Australia; Department of Neurology (O.A.-L.), Cedars-Sinai Medical Center, Los Angeles, CA; Servicio de Neurología (S.C., A.V.-J.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain; Department of Neurology with Institute of Translational Neurology (J.K., H.W.), University Hospital Münster, Germany; Department of Neurology (J.L.P.), First Medical Faculty, Charles University and General University Hospital in Prague, Czech Republic; National Institute for Health and Care Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC) (O.C.), United Kingdom; Ophthalmology Department (E.G.-M.), Miguel Servet University Hospital, Aragones Institute of Health Sciences, Zaragoza, Spain; Department of Neurology (V.K.), University Hospital Zurich, Switzerland; Moorfields Eye Hospital and The National Hospital for Neurology and Neurosurgery (A.P., A.T.T.), University College London, United Kingdom; and Department of Neurology (A.P.), Amsterdam UMC, Vrije Universiteit Amsterdam, MS Centre and Neuro-ophthalmology Expertise Centre Amsterdam, Amsterdam Neuroscience, Netherlands.
这项研究制定了OSCAR-MP标准,用于光学连贯性断层扫描血管学 (OCTA) 扫描的标准化质量控制. 新的标准显著改善了在国际多中心研究中评估OCTA图像质量的评审者间协议.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 光学连贯断层扫描血管造影 (OCTA) 是用于评估视网膜血管系统的关键非侵入性成像技术.
- OCTA越来越多地用于眼科,神经眼科和神经疾病诊断.
- 目前,OCTA质量控制 (QC) 缺乏经过验证的共识标准.
研究的目的:
- 为OCTA成像开发标准化,易于应用的质量控制 (QC) 标准.
- 通过文献审查,评审者之间的协议评估和改进来建立标准.
- 在国际,多中心研究中验证开发的质量控制标准.
主要方法:
- 进行了广泛的文献审查,以确定OCTA文物和质量方面.
- 开发了OSCAR-MP (明显的问题,信号强度,集中,算法失败,视网膜病理,运动工件,投射工件) 标准.
- 评估了互评分协议,确定了分歧原因,并修订了评分指南和培训套件的标准.
- 在国际,跨学科,多中心研究中验证了精细化的标准.
主要成果:
- 确定了影响OCTA质量的7个关键方面:OSCAR-MP.
- 在OSCAR-MP标准的初始应用中,显示了实质性的评价者间一致性 (κ = 0.67).
- 投影工件是分歧的主要来源;定义一个感兴趣的区域 (ROI) 是至关重要的.
- 经过培训和使用评分指南后,对于拒绝质量差的OCTA图像的评审者之间的协议达到了几乎完美的水平 (κ = 0.92).
结论:
- 提出了标准化OCTA质量控制的3步方法:定义ROI,使用OSCAR-MP评估文物,并在ROI中评估质量.
- 在国际多中心环境中,OSCAR-MP标准显示了高互评价协议.
- 欧斯卡-MP是未来临床试验和涉及OCTA的研究的一个有前途的QC协议.


