大脑活动和活动独立的功能连接对工作记忆衰老的共同贡献
Caishui Yang1,2, Jialing Fan1, Kewei Chen3
1State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China.
随着年龄的增长,大脑活动和连接性独立变化,影响工作记忆 (WM). 这些变化在诸如下叶 (IPL) 和前带皮层 (ACC) 等区域影响表现,为认知衰老提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
- 神经成像是一种神经成像.
背景情况:
- 工作记忆 (WM) 损伤在正常衰老中很常见.
- 之前的研究研究了老化WM的区域活动或区域间连接的变化.
- 与大脑活动和连接性在WM表现上的年龄相关变化之间的关系仍然不清楚.
研究的目的:
- 为了调查大脑活动和功能连接是否独立地随着年龄的增长而改变并影响WM性能.
- 探索区域活动和连接性在与年龄相关的WM变化中的调解作用.
- 了解成年后期大脑活动和功能连接之间的相互作用.
主要方法:
- 功能性磁共振成像 (fMRI) 用于在N背任务期间评估WM.
- 一个基于社区的168名老年人 (55-86岁) 的样本参与了调查.
- 与年龄相关的区域大脑活动变化和基于种子的区域间连接性被独立评估.
主要成果:
- 观察到与年龄相关的下顶叶 (IPL) 阳性活性下降,腹前环状皮层 (ACC) 阴性活性增加.
- 在IPL和ACC中,局部功能功能障碍与与其他皮质区域的连接性改变有关.
- IPL和ACC活动受损导致分别对准确性和反应时间产生与年龄有关的影响,连接性变化抵消了这些影响.
结论:
- 区域活动和区域间连接的因年龄引起的变化独立发生,并导致WM衰退.
- 大脑活动和功能连接在成年后期相互作用,影响WM.
- 这些发现为理解认知衰老和WM提供了新的视角.
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