用对比度增强的内支气管超声波对微泡进行成像
Sean McGrath1, Yu-Jack Shen1, Masato Aragaki2
1Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Ultrasound in medicine & biology
|October 9, 2023
概括
与对比度增强的内支气管超声波 (CE-EBUS) 有效地对微泡进行成像,与临床系统相似. 这项技术在诊断非小细胞肺癌患者的淋巴结方面表现有前途.
科学领域:
- 医疗成像医学成像
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 胸腔内膜超声波 (EBUS) 是非小细胞肺癌 (NSCLC) 淋巴结分期的标准.
- 使用微泡 (MB) 的对比增强超声波 (CEUS) 增强了瘤成像,但其在EBUS (CE-EBUS) 的应用需要评估.
研究的目的:
- 评估CE-EBUS系统检测微气泡 (MB) 的能力.
- 为了比较CE-EBUS MB成像性能与临床和临床前CEUS系统在体外和体内.
主要方法:
- 试验室内:用于评估CE-EBUS MB成像,使用了阿加流幻体和参考组织.
- 在体内:使用携带瘤的小鼠 (A549和AE17-OVA) 来评估MB检测能力和 perfusion.
主要成果:
- 在实验室中,CE-EBUS表现出与临床CEUS相似的对比度与组织比率 (CTR).
- 在体内,CE-EBUS输液曲线与临床前CEUS有很强的相关性 (r=0.927).
- CE-EBUS实现了比临床前系统高出2.7倍的CTR.
结论:
- CE-EBUS的对比成像性能与商业超声波系统相提并论.
- 这项技术有可能改善肺癌中枢淋巴结的临床特征.
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