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使用iRGD作为瘤透的癌症治疗

Anbazhagan Thirumalai¹, Koyeli Girigoswami¹, Pragya Pallavi¹

¹Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Medical Bionanotechnology, Faculty of Allied Health Sciences, TN-603103 Kelambakkam, Chennai, India.

Bulletin du cancer

|October 9, 2023

概括

新型称为iRGD (CRGDK/RGPD/EC) 增强瘤透,改善癌症治疗和成像. 这些酸针对特定的受体,有效地将药物和成像剂更深入到瘤中.

科学领域:

在瘤学瘤学.
生物化学生化学
纳米技术纳米技术

背景情况:

瘤透率有限会降低癌症治疗中的疗效.
新型,包括iRGD (CRGDK/RGPD/EC),显示出增强的瘤透和抑制性质.
iRGD可以向瘤血管和细胞上丰富的αvβ整合素 (αvβ3,αvβ5) 和NRP-1受体.

研究的目的:

审查iRGD在癌症治疗和成像中的最新进展和优势.
突出iRGD在改善药物输送和治疗结果方面的潜力.
强调iRGD在增强瘤透的作用,用于各种癌症疗法.

主要方法:

联合注射或iRGD与治疗剂,成像剂或免疫调节剂的化学结合.
用iRGD对纳米载体进行修改,以提供有针对性的有效载荷.
针对癌细胞治疗的iRGD驱动的双重向化疗剂的评估.

主要成果:

iRGD可以促进治疗和成像剂深入瘤组织.
与传统相比,iRGD的简单合成.
显著改善瘤组织透率和有效抑制瘤转移.
已证明iRGD修饰的纳米载体在向更深的瘤区域输送有效载荷时的有效性.

结论:

iRGD是一种有前途的策略,可以改善瘤治疗和成像.
它们能够准特定的受体并改善透的能力,与传统方法相比,具有显著的优势.
对iRGD驱动疗法的进一步研究有可能改善癌症患者的治疗结果.

关键词:

癌症的诊断癌症的诊断双重目标机制的机制治疗疗法治疗疗法 iRGDD 是一个很好的方法.αvβ整合素和神经皮林-1-1

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