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在妊娠中高血压疾病中肠道微生物群的纵向变化:嵌套病例控制和门德尔随机化研究
Xinrui Wu1,2, Qi Li3, Jiawang Cai1
1School of Medicine, Jishou University, Jishou, China.
Scientific reports
|October 9, 2023
概括
这项研究揭示了怀孕期间肠道微生物群 (GM) 在妊娠中高血压疾病 (HDP) 的纵向变化. 特定的细菌,如甲生物菌,与子宫前 (PE) 有因果关系.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 遗传学 遗传学 是一个
背景情况:
- 肠道微生物群 (GM) 越来越多地与妊娠中高血压疾病 (HDP) 有关.
- 以前的研究往往缺乏纵向数据,在妊娠期间仅在一个时间点分析GM.
研究的目的:
- 为了研究在怀孕期间在具有和没有HDP的女性中肠道微生物群组成的纵向变化.
- 识别与HDP相关的特定肠道细菌,并探索与诸如先兆子 (PE) 等疾病的因果关系.
主要方法:
- 一项嵌套病例对照研究与47名HDP患者和30名健康对照进行.
- 用16SrRNA测序在怀孕期间的三个不同的时间点分析了肠道微生物群概况.
- 统计分析包括多样性分析,趋势分析,相关性研究和门德尔随机化 (MR) 分析.
主要成果:
- 在HDP患者和对照人群之间没有观察到总体转基因多样性的显著差异.
- 在怀孕期间发现了21种不同的肠道微生物.
- 特定的属 (Thermomonas,Xanthomonas,Phenylobacterium) 在妊娠高血压组显示出改变的丰度,而其他属 (Xanthomonas,Polycyclovorans,Phenylobacterium) 在对照组不同.
- 六个转基因品种与血压相关,MR分析表明Metanobrevibacter和子宫前 (PE) 之间存在因果关系.
结论:
- 这项研究提供了第一个纵向探索整个怀孕期间HDP患者的转基因变化.
- 鉴定出差异性微生物和Metanobrevibacter和PE之间的因果关系为HDP病原发生提供了新的见解.
- 研究结果表明,基于转基因的预防和治疗策略可能适用于HDP.
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