自闭症谱系障碍的行为严重程度的个性化分类,使用全面的机器学习框架
Mohamed T Ali1,2, Ahmad Gebreil1, Yaser ElNakieb1,2
1Bioengineering Department, University of Louisville, Louisville, KY, 40292, USA.
Scientific reports
|October 9, 2023
概括
这项研究使用人工智能来分析对自闭症谱系障碍 (ASD) 的脑部扫描. 人工智能模型准确地识别了与ASD行为相关的大脑区域,提高了诊断速度和准确性.
科学领域:
- 神经科学是一个神经科学.
- 人工智能的人工智能
- 医疗成像医学成像
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育障碍,具有多种遗传和临床表现.
- 目前的诊断方法可能是漫长的,并从提高精度中受益.
- 了解自闭症行为异质性的神经相关性至关重要.
研究的目的:
- 将自闭症谱系障碍 (ASD) 分解为不同的行为组成部分.
- 在行为领域中识别与ASD严重程度相关的歧视性神经成像特征.
- 开发和验证基于人工智能的ASD诊断和严重程度分类模型.
主要方法:
- 利用ABIDE II数据集,从MRI扫描中提取形态特征.
- 应用多变量特征选择算法和多个AI分类器用于特征识别.
- 采用5倍交叉验证来优化和培训ASD严重程度分类的六个分类器.
主要成果:
- 在跨行为群体的自闭症严重程度分类中达到96%的平均准确率.
- 确定了与ASD相关的特定皮质区域,包括尾部中额部区域.
- 演示了AI模型在ASD中区分大脑区域功能的能力.
结论:
- 拟议的AI模型有效地将ASD剖析为行为组件,以便针对性诊断.
- 这种人工智能驱动的方法提高了ASD患者的诊断速度和准确性.
- 强调人工智能在推进自闭症诊断和改善患者治疗结果方面的巨大潜力.
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