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紧的工程人类机械敏感的交换激活模块使强大的和多功能合成转录控制

Barun Mahata1, Alan Cabrera1, Daniel A Brenner1

  • 1Department of Bioengineering, Rice University, Houston, TX, USA.

Nature methods
|October 9, 2023
PubMed
概括

科学家们从人类机械敏感因子中设计出紧而强大的转录激活域 (TAD),以改进基于CRISPR的基因激活系统 (CRISPRa). 这些新型TAD增强了合成生物学和治疗应用.

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