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Updated: Jun 27, 2026

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
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Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

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通过大规模并行测序,核糖体显示和亲和查,快速发现高亲和抗体

Benjamin T Porebski1, Matthew Balmforth1,2, Gareth Browne3

  • 1MRC Laboratory of Molecular Biology, Cambridge, UK.

Nature biomedical engineering
|October 9, 2023
PubMed
概括

深度查快速选数十亿个抗体-抗原相互作用,加速治疗性抗体的发现. 这种方法可以在几天内识别针对治疗点的高 afinity 抗体片段,从而降低成本和时间表.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...