克罗恩病炎症严重程度评估与密度从光子计数CT肠道学:与内镜组织病理学的比较
Bari Dane1, Kun Qian2, Ria Soni3
1Department of Radiology, NYU Langone Health, 660 1st Avenue, New York, NY, 10016, USA. Bari.Dane@nyulangone.org.
来自对比后CT肠道成像 (PCCT) 的密度测量可以准确地识别克罗恩病 (CD) 患者的活性炎症. 这种技术也有效地区分了轻度和重度的疾病活动.
科学领域:
- 胃肠病学 胃肠病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠病.
- 准确评估CD活动对于有效管理至关重要.
- 后对比CT肠道学 (PCCT) 是一种用于CD评估的成像模式.
研究的目的:
- 通过使用PCCT肠道学来确定最佳的密度值,以检测CD患者的活性炎症.
- 为了评估密度对分层CD活动严重性的有用性.
主要方法:
- 对23名接受PCCT肠道成像的CD患者进行了回顾性分析.
- 放射科医生测量了终端或新终端阴茎中的密度.
- 用接收器操作特征 (ROC) 曲线来确定炎症和严重程度分层的最佳值.
- 使用类内相关系数 (ICC) 评估了读者内部和读者间的协议.
主要成果:
- 2.7 mg/mL的密度值最好地识别了活性炎症 (97%的灵敏度,100%的特异性).
- 3.4毫克/毫升的值区分轻度至中度至重度的炎症 (87%的准确率).
- 观察到高的读取器内 (ICC 0.81-0.86) 和读取器间 (ICC 0.94) 可靠性.
结论:
- 来自PCCT肠道学的密度是CD中活性炎症的可靠的成像生物标志物.
- 基于PCCT肠道学的密度可以有效地分层CD活性,区分轻度和中度至重度疾病.
更多相关视频
07:38Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Published on: September 13, 2016
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
