在中年和老年人中,更新的心血管健康结构和动脉硬之间的时间关系的年龄特异差异
Jiaojiao Huang1,2, Xiaoli Xu1,2, Yingxia Zhou1,2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
GeroScience
|October 9, 2023
概括
改善心血管健康 (CVH) 对中年成人来说至关重要,以预防动脉硬. 低CVH得分预测该群体的动脉硬性增加,突显了早期干预的必要性.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 动脉硬是心血管风险的一个关键指标.
- 可修改的风险因素和动脉硬之间的关系在不同年龄组之间可能有所不同.
- 心血管健康 (CVH) 指标越来越多地被认为对预测血管衰老的作用.
研究的目的:
- 为了研究心血管健康评分 (mLE8) 和动脉硬度之间的相关性,研究年龄特异性差异.
- 检查不同年龄层中CVH和动脉硬之间的时间关系.
- 为了确定CVH对成年人一生中动脉硬的发展的影响.
主要方法:
- 这是一项前性队列研究,共有3757名参与者,平均随访时间为4.3年.
- 使用修改后的AHA"生命必需8" (mLE8) 评分来评估CVH,并测量了动脉硬度的手臂脚脉冲波速度 (baPWV).
- 采用后勤回归,受限立方线和交叉滞后路径分析,按年龄分层 (<60岁与≥60岁).
主要成果:
- 在中年成人 (<60岁) 中,中度和低的mLE8 CVH得分与较高的baPWV升高几率显著相关 (OR=2.21,3.37分别).
- 在老年人 (≥60岁) 中没有观察到CVH和动脉硬之间的这种关联.
- 交叉滞后分析显示,中年人的心血管硬度下降之前,心血管硬度增加,而老年人的心血管硬度同时发生变化.
结论:
- 在mLE8 CVH得分和动脉硬度之间的关系中存在显著的年龄特异性差异.
- 在中年成人中,低心血管健康先于动脉硬的进展.
- 改善CVH的干预措施在中年至关重要,以减轻未来的动脉硬和心血管风险.
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