完全受精失败:一个单一中心的分析分析
Lisiane Knob de Souza1, João Paulo Duarte Witusk2, Bruna Campos Galgaro2
1Insemine Center for Human Reproduction, Porto Alegre, Brazil. lisiane@insemine.com.
Reproductive sciences (Thousand Oaks, Calif.)
|October 9, 2023
概括
在试管婴儿中,完全受精失败与获得的卵细胞数量较少有关,特别是在没有男性因子不孕症的情况下. 获取少于5个卵细胞显著增加了试管婴儿失败的风险.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 人类繁殖人类的繁殖.
背景情况:
- 在试管婴儿中,全方位受精失败 (TFF) 是一个重大挑战,特别是当男性因素不是主要原因时.
- 确定与TFF相关的女性特异性参数对于提高试管婴儿成功率至关重要.
研究的目的:
- 在非男性征兆患者中确定与试管婴儿中TFF相关的男性和女性参数.
- 为了确定IVF失败时卵细胞产量的预测值.
主要方法:
- 一项病例控制研究分析了154个TFF病例和475个2010-2019年间的对照.
- 评估的女性和男性不孕症参数,不包括异常精液分析的情况.
- 后勤回归分析确定了TFF的显著预测因素.
主要成果:
- 女性和男性的年龄,抗穆勒尔激素 (AMH),精液量和初始精子运动性在两组之间没有显著差异.
- 在TFF组中收集的卵细胞数量显著减少 (中位数为2比5).
- 较少的收集卵细胞数量 (少于5) 与TFF显著相关 (OR-1.37).
结论:
- 由较低的卵细胞产量表明的卵泡反应减弱是与非男性不育症IVF失败相关的主要因素.
- 卵细胞数量是预测IVF成功的关键参数,如果没有男性因子不孕症.
相关概念视频
Fertilization
71.1K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
71.1K
In Vitro Fertilization
319
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
319
Infertility in Males
279
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
279
Infertility in Females
332
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
332


