数字口腔健康生物标志物用于早期检测认知衰退
Ping-Chen Chung1, Ta-Chien Chan2,3,4,5
1Department of Dentistry, Puzi Hospital, Ministry of Health and Welfare, Chiayi, Taiwan.
BMC public health
|October 9, 2023
概括
数字口腔健康标记可以帮助检测认知能力下降. 早期对口腔健康和认知状态的监测可以防止未来的疾病负担.
科学领域:
- 口腔健康研究 口腔健康研究
- 认知神经科学是一种认知神经科学.
- 发现生物标志物的发现.
背景情况:
- 口腔健康状况,包括炎症,虚弱和功能,很少被量化为认知功能查.
- 口腔健康可以通过影响大脑活动和血液流动来影响认知功能.
研究的目的:
- 使用非侵入性数字生物标志物来量化口腔健康.
- 采用机器学习算法来检测社区的认知衰退.
主要方法:
- 进行了一项前性病例控制研究,涉及196名参与者 (50-80岁).
- 收集的数据包括人口统计数据,口腔健康指标 (斑块指数,口腔二甲基因化速率,SILL-Ha酸度) 和认知功能.
- 机器学习模型是为了预测认知衰退而开发的.
主要成果:
- 认知能力下降与口服二可基尼斯 (ODK) 率和SILL-Ha酸度有显著的关联.
- 诸如年龄较小,社交互动增加,菌细菌较少,白细胞高,缓冲能力高等因素与认知衰退风险较低有关.
- 一个预测模型实现了0.86曲线下的面积,用于认知衰退检测.
结论:
- 对于认知功能评估来说,使用数字口腔健康生物标志物方法是可行的.
- 同时评估口腔卫生和认知状态,可以进行早期监测.
- 早期检测有可能防止未来的疾病负担.
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