疟疾的致命呼吸道并发症是由活性菌引起的
Angie R López1, Ezequias B Martins1,2, Anielle de Pina-Costa1,2
1Instituto Nacional de Infectologia Evandro Chagas Fiocruz, Rio de Janeiro, Brazil.
Malaria journal
|October 9, 2023
概括
严重的Plasmodium vivax疟疾会导致呼吸道并发症,即使在以前健康的人身上也是如此. 早期诊断和意识到潜在的药物参与并发症对于有效的疟疾管理至关重要.
科学领域:
- 热带医学 热带医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 疟疾仍然是巴西的一个重大公共卫生问题.
- 严重的Plasmodium vivax疟疾越来越多地被报告,但在文献中呼吸道并发症很少见.
- 了解严重疟疾进展的风险因素对于预防至关重要.
研究的目的:
- 报告一种严重的进口Plasmodium vivax疟疾病例,导致致命的呼吸道并发症.
- 调查抗疟疾药物在呼吸困难综合征发展中的潜在作用.
- 强调早期疟疾诊断的重要性,特别是在非流行地区.
主要方法:
- 一个先前健康的40岁妇女患有进口vivax疟疾的病例报告.
- 对疾病进展和治疗反应的临床观察.
- 对开始服用抗疟疾药物和出现呼吸系统症状之间的时间关系的分析.
主要成果:
- 患者发展了急性呼吸困扰综合征 (ARDS),尽管用诺基因和普里马基因治疗.
- 呼吸系统症状在开始抗疟疾治疗后48小时开始.
- 患者在治疗的第五天死于ARDS.
结论:
- 抗疟疾药物可能与严重的vivax疟疾中呼吸道并发症的发展有关.
- 活性疟原虫疟疾不应被认为是纯良性的;严重的结果是可能的.
- 及时诊断疟疾至关重要,特别是在意识较低的非特有地区.
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