与年龄相关的口腔状细胞癌的生存分析:基于SEER的人口研究
Jingjing Yang1, Kaibo Guo2, Anlai Zhang3
1Hangzhou Cancer Hospital, Hangzhou, 310000, ZJ, China.
European journal of medical research
|October 9, 2023
概括
老年显著恶化口腔状细胞癌的预后. 这项研究强调年龄是影响口腔癌患者生存结果的关键因素,影响诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 了解预后因素对于改善患者治疗结果至关重要.
- 年龄对OSCC预后的具体影响需要进一步调查.
研究的目的:
- 调查口腔状细胞癌 (OSCC) 的预后因素.
- 具体评估年龄作为OSCC生存预测因素的作用.
- 确定与OSCC死亡率相关的其他临床因素.
主要方法:
- 从SEER数据库 (2005-2015) 中分析了33,619个OSCC案件.
- 卡普兰-梅尔对整体存活率 (OS) 和癌症特定存活率 (CSS) 的生存分析.
- 使用单变量和多变量考克斯回归和竞争风险模型.
主要成果:
- 高龄是OSCC预后更差的重要预测因素,老年人群的危险比率增加.
- 多变量分析显示,50-59岁,60-69岁和70岁以上的年龄组的死亡风险增加.
- 女性性别,未婚状态,黑人种族,瘤位置 (口腔底部),较大的瘤大小和较高的TNM分类也与较差的生存率有关.
结论:
- 年龄是影响口腔状细胞癌生存的关键因素.
- 对年龄的临床关注对于OSCC患者的诊断,治疗计划和预后评估至关重要.
- 进一步的研究应该探索OSCC的特定年龄管理策略.
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