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相关概念视频

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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相关实验视频

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基于癌细胞膜的材料用于生物医学应用.

Yongping Lu1,2, Linming Fan1, Jun Wang1

  • 1Science and Technologv Innovation Center, Guangyuan Central Hospital, Guangyuan, 628000, China.

Small (Weinheim an der Bergstrasse, Germany)
|October 9, 2023
PubMed
概括

癌细胞膜纳米平台 (CCM-NP) 通过改善循环时间和瘤向来增强药物输送. 这些纳米输送系统在癌症治疗方面表现有前途,目前正在进行临床应用的研究.

关键词:
生物医学应用程序生物纳米塑料纳米平台癌症细胞膜 癌症细胞膜癌症治疗疗法 癌症治疗

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 在瘤学瘤学.

背景情况:

  • 纳米输送系统面临的挑战是,生物半衰期短,瘤向不佳.
  • 自然细胞膜,特别是癌细胞膜 (CCM),提供免疫逃避和同源向.
  • 基于CCM的纳米平台 (CCM-NP) 将CCM与纳米粒子集成,以克服交付限制.

研究的目的:

  • 审查CCM-NP的开发和应用.
  • 详细介绍CCM-NP在癌症治疗中的使用.
  • 讨论CCM-NPs的翻译潜力和未来的研究需求.

主要方法:

  • 关于CCM-NP历史和发展的文献综述.
  • 对生物医学领域中CCM-NP应用的分析,重点是癌症治疗.
  • 讨论转化努力和临床采用的挑战.

主要成果:

  • CCM-NP可以改善纳米粒子的血液循环时间.
  • CCM-NP促进了对瘤的同类向.
  • CCM-NP显示了癌症治疗应用的巨大潜力.

结论:

  • CCM-NPs代表了一个有前途的纳米平台,用于增强癌症诊断和治疗.
  • 进一步的研究对于CCM-NP的成功临床转化至关重要.
  • CCM-NPs提供了一种新的策略,以提高纳米输送系统在瘤学中的有效性.