情绪和焦虑以及成年人患有耐药叶的认知表型之间的关系
Nolan Bingaman1, Lisa Ferguson2, Nicolas Thompson3
1Department of Psychology, Case Western Reserve University, Cleveland, Ohio, USA.
Epilepsia
|October 10, 2023
概括
抑郁症和某些药物与叶 (TLE) 的认知表型恶化有关. 这些发现强调了在TLE认知评估中考虑精神病学因素的重要性.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 叶 (TLE) 经常与认知和精神问题同时发生.
- 现有的研究确定了TLE的认知表型,但缺乏关于它们与焦虑和抑郁等精神病相关疾病的联系的清晰度.
研究的目的:
- 调查TLE成年人的认知表型和精神病症状之间的关系.
主要方法:
- 826名患有耐药性TLE的成年人接受了神经心理测试,以确定症认知障碍国际分类 (IC-CoDE) 的表型.
- 查抑郁和焦虑,以及从电子健康记录中提取精神病史和药物数据.
- 多变量比例概率逻辑回归分析了IC-CoDE表型与精神病变量之间的关联,控制共变量.
主要成果:
- 抑郁症状升高与更严重认知表型的可能性更高相关 (OR=1.123-1.993,p<.05).
- 心理药物和抗发作药物 (OR=1.584,p<.05;OR=1.507,p<.001),情绪恶化的抗发作药物 (OR=1.748,p=.005),以及精神病史 (OR=1.928,p<.05) 也增加了严重认知表型的几率.
- 焦虑症状与认知表型没有显著的关系.
结论:
- 精神病学因素,特别是抑郁症状和药物使用,与TLE认知缺陷的模式和程度有显著的关联.
- 这些发现表明抑郁症状和药物应该被视为TLE认知表型的诊断修饰剂.
- 建议通过神经成像进行进一步的纵向研究,以阐明TLE中认知,情绪和之间的复杂相互作用.
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