围假肢关节感染的突流体生物标志物的诊断价值:一个前性的双盲试验
Ying Xu1,2,3, Xueting Ma4, Haoran Guo1,3,5
1Department of Laboratory Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing, China (mainland).
概括
合成液体S100结合蛋白A8 (S100A8),S100结合蛋白A9 (S100A9),以及人中性粒细胞 (HNP)1-3显示出围围假肢关节感染 (PJI) 的高诊断价值. 这些生物标志物,特别是S100A8,在与其他感染标志物相结合时,有助于准确诊断PJI.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 生物化学 生物化学
背景情况:
- 周围假肢关节感染 (PJI) 是整体关节整形术后的一种严重并发症.
- 准确和及时诊断PJI对于有效的治疗和患者的结果至关重要.
- 目前PJI的诊断方法有局限性,需要寻找新的生物标志物.
研究的目的:
- 调查PJI的S100A8和S100A9突液的临床诊断价值.
- 确定具有PJI诊断价值的α-defensin的特定亚型.
- 评估这些生物标志物与常规感染标志物的联合诊断效率.
主要方法:
- 这是一项前性双盲研究,涉及82名疑似PJI患者.
- 使用矩阵辅助激光吸附/离子化飞行时间质谱法进行交汇液体分析.
- 接收器操作特征 (ROC) 曲线分析以确定诊断效率和曲线下的面积 (AUC).
主要成果:
- 与非PJI组相比,PJI组的S100A8,S100A9变种和HNP1-3显著增加 (P<0.001).
- S100A8显示出高诊断性能,灵敏度为97.4%,特异性为86.0%,AUC为0.964.
- 将这些生物标志物与白细胞计数和中性粒细胞百分比相结合,提高了诊断效率.
结论:
- 同胞液S100A8,S100A9和HNP1-3是诊断PJI的有价值的生物标志物.
- 这些生物标志物提供了令人满意的诊断效率,帮助临床医生准确PJI诊断.
- 这些发现支持使用这些生物标志物来提高PJI的诊断准确性.
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