人类测量措施,预测内脏脂肪组织和慢性炎症生物标志物的生物标志物
Seán R Millar1, Ivan J Perry1, Catherine M Phillips1,2
1HRB Centre for Health and Diet Research, School of Public Health, University College Cork, Cork, Ireland.
European journal of clinical investigation
|October 10, 2023
概括
预测的内脏脂肪组织 (VAT) 方程比标准措施更好地解释炎症生物标志物. 这些方程可能有助于评估代谢健康和慢性疾病风险.
科学领域:
- 肥胖和新陈代谢 肥胖和新陈代谢
- 炎症和免疫学 炎症和免疫学
背景情况:
- 低度系统性炎症和内脏脂肪组织 (VAT) 与慢性疾病有关.
- 增值税释放细胞因子和蛋白质,可能促进炎症.
- 为了估计增值税水平,存在几种方程.
研究的目的:
- 为了比较预测的内脏脂肪组织 (VAT) 方程与人类测量方法在解释炎症生物标志物变异方面的能力.
- 评估增值税方程在表征代谢健康方面的有用性.
主要方法:
- 一项涉及2038名46-73岁男性和女性的横截面研究.
- 使用了相关性和线性回归分析.
- 检查了10个预测的增值税方程和炎症生物标志物之间的关系,与4个人类指标相比.
主要成果:
- 预测的增值税方程解释了炎症生物标志物 (例如,CRP,IL-6,TNF-α,抵抗素) 与男性和女性的人类测量相比,在炎症生物标志物 (例如,CRP,IL-6,TNF-α,抵抗素) 中变异的比例更大.
- 在女性中观察到各种炎症标志物,包括C3,阿迪波涅克丁和阿迪波涅克丁与莱普丁的比率,有显著的关联.
结论:
- 估计内脏脂肪组织 (VAT) 水平的方程在表征代谢健康方面具有潜在的实用性.
- 需要进一步的研究来调查预测的增值税和疾病/死亡结果之间的关系.
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