肝硬化患者肝细胞癌的临床特征:一个比较队列研究
1Department of gastroenterology and hepatology, Centre Hospitalier Jolimont, Haine-Saint-Paul, Belgium.
Acta gastro-enterologica Belgica
|October 10, 2023
概括
肝硬化导致肝癌 (肝细胞癌或HCC) 的原因在过去二十年中发生了重大变化. 虽然HCC的表现仍然相似,但酒精现在是比C型肝炎更常见的原因.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肝硬化病的流行病学在过去的20年里有所发展.
- 了解肝细胞癌 (HCC) 病因的变化对于患者的管理至关重要.
研究的目的:
- 评估肝硬化患者中HCC流行病学和临床表现的变化.
- 在20年的时间里,比较两组肝硬化患者.
主要方法:
- 数据是从比利时Jolimont医院肝硬化病名册中提取的.
- 分析了两个队列:1995-2005年 (n=504) 和2006-2016年 (n=566).
- 两组患者之间比较了患有HCC的患者.
主要成果:
- 在诊断时的年龄,检测方法或对HCC的瘤阶段之间没有观察到任何显著的差异.
- 与型肝炎病毒 (HCV) 相关的HCC从53%降至18%.
- 与酒精有关的HCC从27%增加到60%,而与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关的HCC为10%.
结论:
- 整体HCC的流行病学没有改变.
- 肝硬化导致HCC的潜在原因 (病因) 已经显著转变,酒精变得越来越普遍.
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