COVID-19在患有抗卡巴烯姆抗性Acinetobacter baumannii细菌病的患者的临床影响
Jeong Yeon Kim1, Woo Joo Lee1, Jin Woong Suh1
1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
新冠状病毒病2019 (COVID-19) 对患有抗卡巴因的重症患者产生负面影响 Acinetobacter baumannii (CRAB) 血流感染. 在这些易受伤害的患者中,COVID-19诊断是增加28天死亡率的重要预测因素.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 微生物学 微生物学
背景情况:
- 耐卡巴胺的巴曼尼菌 (Acinetobacter baumannii,简称CRAB) 对重症患者构成重大威胁.
- 2019年同期冠状病毒病 (COVID-19) 对CRAB血流感染 (BSI) 结果的影响尚不清楚.
研究的目的:
- 为了评估COVID-19对CRAB BSI重症患者治疗结果的影响.
- 为了确定这种患者群体中死亡率的预测因素.
主要方法:
- 从2021年1月到2022年3月,对70名患有CRAB BSI的成年ICU患者进行了回顾性队列研究.
- 分析包括患有和没有COVID-19诊断的患者.
- 多变量Cox比例危险回归被用于确定死亡率预测因素.
主要成果:
- 24名 (34.3%) 患者被诊断为COVID-19患者.
- 整体28天死亡率为64.3%.
- COVID-19诊断 (HR 2.91),中性质减退 (HR 2.76) 和皮特细菌病得分 (HR 1.30) 是28天死亡率的独立预测因素. 适当的抗生素治疗具有保护性 (HR 0.31).
结论:
- COVID-19对患有CRAB BSI的患者有负面预后影响.
- 需要进一步的研究来阐明COVID-19加剧CRAB感染结果的机制.
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