评估男孩和青少年的丸功能
Jimena Lopez Dacal1, Sebastián Castro1, Sofía Suco1
1Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE), CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Clinical endocrinology
|October 10, 2023
概括
在儿童中评估下丘脑-垂体-丸轴需要了解发育变化. 本综述详细介绍了新生儿,儿童和青春期男性的适当评估方法,有助于准确诊断阴道轴障碍.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖医学 生殖医学
- 发展生物学 发展生物学
背景情况:
- 脑下垂体丸轴从胎儿发育到青春期经历了显著的功能变化.
- 标准的成人评估如血清丸激素和精液分析不适合婴儿和儿童.
- 发生性腺轴的疾病根据发病的发育阶段表现得不同.
研究的目的:
- 审查和概述适当的方法来评估小儿病人的下丘脑-垂体-丸轴.
- 为评估从新生儿时期到青春期的阴道轴功能提供指导.
- 突出发育阶段在诊断轴功能障碍方面的重要性.
主要方法:
- 专注于激素实验室研究,包括血清淋巴腺素和.
- 将遗传学研究,临床症状和成像用于病因诊断.
- 使用像抗穆勒尔激素 (AMH) 和B抑制素这样的生物标志物来评估丸功能.
主要成果:
- 血清淋巴激素和水平在婴儿期 (0-6个月) 和青春期具有信息性.
- 从出生到青春期结束,AMH和B抑制素是丸功能的可靠生物标志物.
- 临床和成像发现有助于评估胎儿和产后丸激素的作用.
结论:
- 准确诊断儿科下丘脑-垂体-丸轴障碍需要对其发育生理学的深入理解.
- 了解正常轴发展对于解释儿科患者的评估结果至关重要.
- 综合激素,遗传,临床和成像数据的综合评估是必不可少的.
相关概念视频
Testes: Gross Anatomy
2.2K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
2.2K
Testes: Histology
969
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The spermatogenic cells, responsible for producing sperm, are...
969
Testosterone: Functions and Regulation
700
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
700
Disorders of the Male Reproductive System
434
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
434
Infertility in Males
279
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
279
Signs of Puberty
383
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
383


