在患有牛皮关节炎的患者中,阿普雷米拉斯特的治疗持续性
Amir Haddad1, Nili Stein2, Idit Lavi2
1Rheumatology Unit, Carmel Medical Center, Haifa, Israel.
Biologics : targets & therapy
|October 10, 2023
概括
在牛皮关节炎 (PsA) 患者中,阿普雷米拉斯的持续性很低,许多人因关节无效而停止治疗. 这凸显了需要更好地选择患者,以提高治疗的有效性和持续性.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 现实世界的证据.
背景情况:
- 牛皮关节炎 (PsA) 是一种慢性炎症性疾病.
- 治疗持续性对于有效管理PsA至关重要.
- 阿普雷米拉斯特是一种针对PsA的向疗法,但现实世界持久性数据有限.
研究的目的:
- 为了估计PsA患者的阿普雷米拉斯特持续性.
- 在现实环境中识别与Apremilast停药相关的因素.
主要方法:
- 一个大型健康数据库的回顾性分析 (2016年1月 - 2021年6月).
- 包括568名PsA患者接受了阿普雷米拉斯特治疗.
- 生存分析 (Kaplan-Meier) 和停药原因的图表审查.
主要成果:
- 中位数的阿普雷米拉斯持续时间为6.1个月;只有16.9%的长期持续.
- 停止治疗的主要原因是缺乏联合疗效 (33.3%) 和副作用 (24.1%).
- 没有观察到年龄,性别,肥胖或之前的生物使用对持续性的显著影响.
结论:
- 在这个PsA队列中,apremilast的持续性很低.
- 关节无效是停止治疗的主要原因之一.
- 建议对患者选择进行进一步的研究,以提高治疗的有效性和持续性.
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