对上道泌尿器官癌的辅助性内疗法
Raymond Khargi1, Christopher Connors1, Anna Ricapito1,2
1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Translational andrology and urology
|October 10, 2023
概括
辅助性内疗法,包括Mitomycin C和UGN-101,越来越多地用于上泌尿道尿癌 (UTUC). 需要进一步的研究来证实这些局部治疗对工人联合会管理的有效性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 上泌尿道泌尿道癌 (UTUC) 经常被诊断并最初通过内镜手术进行治疗.
- 随着风险分层,辅助疗法在UTUC治疗中变得越来越普遍.
- 描述目前和未来的辅助疗法格局对于优化患者护理至关重要.
研究的目的:
- 提供关于内灌注作为UTUC的辅助疗法的最新概述.
- 审查最新的关于UTUC流行病学,特征,治疗和结果的数据,重点关注内辅助方法.
- 突出新兴疗法和进一步临床评估的需要.
主要方法:
- 综合性文献综述,重点关注UTUC流行病学,疾病特征和治疗结果.
- 特别强调UTUC的内辅助疗法.
- 分析当前和潜在的未来治疗选择,包括局部药物和药物释放支架.
主要成果:
- 线粒素C是UTUC最常用的辅助治疗方法,使用菌卡尔梅特-格林 (BCG) 较少.
- 基于凝的新型局部疗法UGN-101已获得FDA对UTUC的批准.
- 其他药物,如BCG-IFN,gemcitabine,docetaxel和药物释放支架显示未来使用的潜力,等待进一步的研究.
结论:
- 内治疗在UTUC的管理中越来越重要.
- 目前对UTUC的局部辅助治疗的证据显示,有效性是可变的,通常受到小样本大小和回顾性数据的限制.
- 进一步的临床试验至关重要,以确定这些辅助疗法对UTUC的最终益处.
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