在先天性心脏缺陷的性别差异:一个叙事审查
Flaminia Pugnaloni1,2, Alessandro Felici1, Antonio-Francesco Corno3
1Department of Maternal Infantile and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
Translational pediatrics
|October 10, 2023
概括
男人面临严重先天性心脏缺陷 (CHD) 的更高风险,而女性更容易患上较轻的形式. 了解这些性别差异对于定制的冠状动脉疾病预防和治疗策略至关重要.
科学领域:
- 心脏病学 心脏病学
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
背景情况:
- 先天性心脏缺陷 (CHD) 是最常见的出生缺陷,影响近1%的新生儿.
- 心血管疾病的性别特异性流行对于个性化医学至关重要,影响预防,诊断和治疗.
- 对心血管疾病护理的整体方法需要了解现有的性别差异.
研究的目的:
- 在先天性心脏缺陷的流行病学中提供性别差异的全面概述.
- 综合当前关于性别如何影响心脏病的流行率和类型的研究.
- 突出性别在CHD风险分层和管理中的重要性.
主要方法:
- 在PubMed,Scopus和Embase数据库中进行了系统的文献搜索.
- 关键词包括"先天性心脏病"",性别差异"和"流行率".
- 包括的研究是观察性,前性,基于人口的或回顾性,专注于人类受试者,并以英语出版.
主要成果:
- 该审查包括21项研究,经过严格的选和参考清单分析后进行了审查.
- 在特定的先天性心脏缺陷子组中观察到显著的性别差异.
- 男人患重型心血管疾病的风险更高,而女性更常受到轻型心血管疾病亚型的影响.
结论:
- 证据证实,在特定类型的冠状动脉疾病的患病率方面,性别差异显著.
- 这些基于性别的CHD分布差异的潜在病因需要进一步调查.
- 面向未来的,基于性别的CHD管理方法对于优化患者结果至关重要.
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