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[宫癌免疫治疗的预测标记]

E M Oliushina¹, L E Zavalishina¹, Yu Yu Andreeva¹

¹Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Arkhiv patologii

|October 10, 2023

概括

编程死亡连接体1 (PD-L1) 在超过一半的宫癌 (CC) 病例中表达,特别是在瘤中具有高瘤透淋巴细胞 (TIL) 和差分化的瘤中. 这表明PD-L1状态对于CC的个性化免疫疗法至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

宫癌 (CC) 仍然是一个重大的全球健康挑战.
了解瘤微环境,包括免疫细胞透和分子标记,对于开发有效的治疗方法至关重要.
编程死亡配体1 (PD-L1) 是一种免疫检查点蛋白质,与瘤免疫逃避有关.

研究的目的:

为了研究PD-L1在状细胞和状细胞宫癌中的表达.
评估PD-L1表达和临床形态特征,瘤透淋巴细胞 (TILs),微卫星不稳定性/不匹配修复缺陷 (MSI/dMMR) 和人类乳头瘤病毒 (HPV) 状态之间的相关性.
评估PD-L1作为生物标志物的潜力,用于预测对免疫检查点抑制剂的反应.

主要方法:

在41个CC患者样本中对PD-L1表达的免疫组织化学 (IHC) 分析.
使用IHC评估TILs指数,MMR蛋白表达和p16状态.
在PD-L1状态和临床病理特征,MSI/dMMR和HPV状态之间的相关性分析.

主要成果:

在51.2%的CC样本中观察到积极的PD-L1表达.
PD-L1表达与瘤分化程度 (p=0.027) 和TILs透程度 (p=0.038) 有显著的相关性,在TILs≥50%的瘤中表达更高.
在PD-L1状态和患者年龄,组织学亚型,瘤阶段 (pT,pN),淋巴血管入侵或HPV状态之间没有发现统计学意义上的关联. 患有MSI/dMMR的瘤 (4.9%) 显示PD-L1状态为阳性.

结论:

在大多数临床和形态因素不考虑的情况下,PD-L1表达在大量的宫癌中.
在PD-L1表达,瘤分化度和TILs之间存在显著的关系.
患有MSI/dMMR的宫癌呈现出积极的PD-L1状态,这突出了为个性化免疫疗法选择需要PD-L1评估的需要.

关键词:

这是一个HPVHPVHPV.在MSI中,它是MSI.在PD-L1中.宫癌:子宫癌是一种癌症.dMMR 是一个MMR.

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